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bleomycin sulfate from streptomyces verticillus

Bleomycin sulfate

CAS: 9041-93-4

Molecular Formula: C110H168N34O46S7

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bleomycin sulfate from streptomyces verticillus - Names and Identifiers

Name Bleomycin sulfate
Synonyms Blocamicina
BLEMOYCIN SULFATE
Bleomycin sulfate
Bleomycine Sulfate
BLEOMYCIN SULFATE, BPC
Bleomycin Sulfate, Blenoxane
BLEOMYCIN SULFATE CELL CULTURE TESTED
bleomycin sulfate from streptomyces verticillus
BLEOMYCIN SULFATE FROM STREPTOMYCES VERT ICILLUS, LYOPH.
BLEOMYCIN SULFATE FROM STREPTOMYCES VERTICILLUS 0 TO 5 °C
3-[[2-[2-[2-[[2-[[(2S,3S,4R)-4-[[(2R,3S)-3-[(2S,3S,4R,5S,6R)-3-[(2S,3S,4R,5S,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-(1H-imidazol-4-yl)-2-[[2-(propylaminomethyl)pyrimidine-4-carbonyl]amino]propanoyl]amino]-3-hydroxy-2-methyl-pentanoyl]amino]-3-hydroxy-butanoyl]amino]ethyl]thiazol-4-yl]thiazole-5-carbonyl]amino]propyl-dimethyl-sulfonium
3-[[2-[2-[2-[2-[4-[2-[6-Amino-2-[1-(2-amino-2-carbamoyl-ethyl)amino-2-carbamoyl-ethyl]-5-methyl-pyrimidin-4-yl]carbonylamino-3-[3-[4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-(3H-imidazol-4-yl)propanoyl]amino-3-hydroxy-2-methyl-pentanoyl]amino-3-hydroxy-butanoyl]aminoethyl]-1,3-thiazol-4-yl]-1,3-thiazol-4-yl]carbonylamino]propyl-dimethyl-sulfonium hydrogen sulfate
CAS 9041-93-4
EINECS 232-925-2
InChI InChI=1/C52H77N13O19S3/c1-7-11-54-18-32-56-13-9-26(62-32)45(75)65-35(41(27-16-55-22-60-27)82-51-43(39(72)37(70)29(19-66)81-51)83-50-40(73)42(84-52(53)79)38(71)30(20-67)80-50)48(78)61-24(3)36(69)23(2)44(74)64-34(25(4)68)47(77)58-14-10-33-63-28(21-85-33)49-59-17-31(86-49)46(76)57-12-8-15-87(5)6/h9,13,16-17,21-25,29-30,34-43,50-51,54,66-73H,7-8,10-12,14-15,18-20H2,1-6H3,(H7-,53,55,57,58,60,61,64,65,74,75,76,77,78,79)/p+1/t23-,24+,25?,29+,30+,34?,35+,36-,37+,38-,39+,40-,41+,42+,43-,50-,51+/m0/s1

bleomycin sulfate from streptomyces verticillus - Physico-chemical Properties

Molecular FormulaC110H168N34O46S7
Molar Mass2927.17
Melting Point200-204°C (dec.)
Water SolubilitySoluble in water or DMSO
Solubility Soluble in water, methanol, slightly soluble in ethanol, almost insoluble in acetone, ethyl acetate, butyl acetate, ether.
AppearanceWhite to yellowish powder
Colorwhite
Merck14,1318
Storage Condition2-8°C
StabilityStable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.
SensitiveSensitive to heat
MDLMFCD00070310
Physical and Chemical PropertiesBleomycin contains several components with similar properties and is a weakly alkaline substance. Soluble in water, methanol, slightly soluble in ethanol, almost insoluble in acetone, ethyl acetate, butyl acetate, ether. It is blue-green when containing copper ions, and white powder after removing copper ions.
UseThe recommended concentration as a selector is 10-100 μg/ml. Bbleomycin is used as a selector for transformed cells, especially for the transformation of plant cells.
In vitro studyBoth UT-SCC-12A and UT-SCC-12B were resistant to Bleomycin sulfate with IC50 of 14.2 nM and 13 nM, respectively. Alveolar macrophages cultured with 0.01 μg/mL to 1 μg/mL Bleomycin sulfate for 18 hours secreted significantly more fibroblast growth factor than macrophages cultured alone. Macrophages stimulated by Bleomycin sulfate continued to produce large amounts of fibroblast growth factor, even after Bleomycin sulfate was removed and replaced with fresh medium (without Bleomycin sulfate). Stimulation of alveolar macrophages by Bleomycin sulfate leads to inhibition of cellulose growth factor secretion by cycloheximide, and the 5-lipoxygenase inhibitors NDGA (nordihydroguaiaretic acid) and BW755c, it is shown that it requires not only protein synthesis but also the complete expression of the activity of the 5-lipoxygenase pathway of arachidonic acid metabolism. Bleomycin sulfate (400 µg/mL), cultured for 24 hours, decreased the activity of NTera-2 cells, increased the activity of caspase-3,-8 and -9, increased the levels of Bax and cytoplasmic cytochrome C, and reduce Bcl-2 levels. For instability aberrations, the chromosomal disrupting effect of Bleomycin sulfate on ADIPO-P2 cells persisted for at least 10 days after treatment. Furthermore, the appearance of telomere fusions after 10 days of treatment of cells exposed to Bleomycin sulfate suggests that Bleomycin sulfate is capable of inducing delayed telomere destabilization.
In vivo studyOn the 7th day after Bleomycin sulfate treatment, CD45 + cells in BALf of NOX-/-were more than 1.7 times as many as WT, of which 57% were Mf, and on the 21st day, they were reduced to 67% in WT, reduced to 83% in NOX.

bleomycin sulfate from streptomyces verticillus - Risk and Safety

Risk CodesR46 - May cause heritable genetic damage
R40 - Limited evidence of a carcinogenic effect
R36/37/38 - Irritating to eyes, respiratory system and skin.
R63 - Possible risk of harm to the unborn child
Safety DescriptionS53 - Avoid exposure - obtain special instructions before use.
S36/37 - Wear suitable protective clothing and gloves.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany3
RTECSEC5991990
FLUKA BRAND F CODES10
HS Code2941906000

bleomycin sulfate from streptomyces verticillus - Introduction

Bbleomycin contains several components with similar properties (A mixture of bleomycin sulfate salts), which are weakly alkaline substances
Last Update：2022-10-16 17:30:01
bleomycin sulfate from streptomyces verticillus
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View History
bleomycin sulfate from streptomyces verticillus
2-[2-[2-(2-氨基乙氧基)乙氧基]乙氧基]乙硫醇
SILICONE DIOXIDE
4-氯-2,6-二甲基吡啶
L-PYROGLUTAMIC ACID BETA-NAPHTHYLAMIDE
[2-(1-吡咯烷基甲基)苯基]溴化镁 溶液
COPPER PAN (CU-EDTA + PAN)
TOSLAB 768462
TSLDASIIWAMMQN
2-IODOTHIOANISOLE
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